https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13792 Wed 11 Apr 2018 12:42:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33176 6× upper limit of normal (ULN) and 4 had >10× ULN. TTG Ab-positive patients were classified as having either potential CD with (n = 3, 16%) and without lymphocytic duodenosis (LD; n = 12, 63%), and no CD (n = 4, 21%) on human leukocyte antigen typing. There was an increase in duodenal eosinophils in patients with elevated TTG Ab (P = 0.01), which remained when patients with LD were excluded (P = 0.018). Of 19 patients with EoE and elevated TTG Ab, 5 responded to elimination diet involving exclusion of wheat, including 2 with a sole wheat trigger and TTG Ab >10× ULN that were CD-associated human leukocyte antigen-negative. Conclusions: Serum TTG Ab was elevated in almost one-quarter of our total EoE cohort, and at least 20% of these patients did not have potential CD, suggesting EoE is a heterogeneous disease with differing immune mechanisms activated in some patients. These findings also support routine esophageal biopsy during upper endoscopy in children with elevated TTG Ab.]]> Tue 11 Sep 2018 12:15:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12909 Sat 24 Mar 2018 10:37:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12765 Sat 24 Mar 2018 08:18:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12425 Sat 24 Mar 2018 08:17:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31059 45 days, change in length z scores within 3 months of HPE, and center. On multivariate analysis, TB (P < 0.0001) and albumin (P=0.02) at 3 months post-HPE, and center (P=0.0003) were independently associated with native liver survival. Receiver operating characteristic analysis revealed an optimal cut-off value of TB < 74 µmol/L (4.3 mg/dL; area under the receiver operating characteristic curve 0.8990) and serum albumin level > 35 g/L (3.5 mg/dL; area under the receiver operating characteristic curve 0.7633) to predict 2-year native liver survival. TB and albumin levels 3 months post-HPE defined 3 groups (1: TB =74 µmol/L, albumin > 35 g/L; 2: TB =74 µmol/L, albumin =35 g/L; 3: TB > 74 µmol/L) with distinct short-and long-term native liver survival rates (log-rank P < 0.001). Length z scores 3 months post-HPE were poorer for group 2 than group 1 (-0.91 vs-0.30, P=0.0217) with similar rates of coagulopathy. Conclusions: Serum TB and albumin levels 3 months post-HPE independently predicted native liver survival in BA when controlling for center. Serum albumin level < 35 g/L in infants with BA who were no longer jaundiced at 3 months post-HPE was a poor prognostic indicator. Poorer linear growth and absence of significant coagulopathy suggest a role for early aggressive nutritional therapy in this group.]]> Sat 24 Mar 2018 07:25:47 AEDT ]]>